PEGylation of protein-based MRI contrast agents improves relaxivities and biocompatibilities
نویسندگان
چکیده
منابع مشابه
Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics.
UNLABELLED Polyethylene glycol (PEG) surface modification can make nanomaterials highly hydrophilic, reducing their sequestration in the reticuloendothelial system. In this study, polyamidoamine (PAMAM) dendrimers bearing gadolinium (Gd) chelates were PEGylated with different PEG-chain lengths, and the effects on paramagnetic and pharmacokinetic properties were evaluated. Specifically, Gd chela...
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Contrast agents are of great importance in clinical applications of Magnetic Resonance Imaging (MRI) to improve the contrast of internal body structures and to obtain tissue-specific image. However, current approved contrast agents still have limitations including low relaxivity, low specificity and uncontrolled blood circulation time, which motivated researchers to develop novel contrast agent...
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ژورنال
عنوان ژورنال: Journal of Inorganic Biochemistry
سال: 2012
ISSN: 0162-0134
DOI: 10.1016/j.jinorgbio.2011.11.004